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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Nat Neurosci. 2010 Apr 11;13(5):567–576. doi: 10.1038/nn.2528

Figure 5. Altered properties of autophagic–related compartments in HD cells.

Figure 5

(a) Immunoblot for the indicated proteins in fractions enriched in autophagosomes (APH) and autophagolysosomes (APHL) isolated from liver of 18Qhtt and 111Qhtt mice. Bottom: Changes (folds increase or decrease) in the levels of each protein. Mean+s.d. n = 4. (b) Homogenates (Homo), cytosol (Cyt) and fractions enriched in autophagosomes (APH) and in autophagolysosomes (APHL) isolated from wild type (18Qhtt) and mutant huntingtin knock–in mice (111Qhtt) livers were subjected to immunoblot for htt. A representative immunoblot of 4 experiments with duplicated samples is shown. * p < 0.05. Full–length blots are presented in Supplementary Fig. 20.