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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Cell Signal. 2010 Mar 3;22(7):1076–1087. doi: 10.1016/j.cellsig.2010.02.010

Fig. 7.

Fig. 7

Effects of exogenous IGFBP-3 on cell signaling and TRAIL-mediated apoptosis in HSF. (A) Effects of IGFBP-3 (100 ng/ml in the cell media) on the AKT-dependent pathway, as well as on p53 and BAX in non-irradiated, irradiated and bystander cells were determined by Western blot analysis 24 h after treatment. (B, C) Effects of IGFBP-3 (100 ng/ml) on TRAIL-induced apoptosis in directly irradiated and bystander cells. Apoptotic levels were determined 48 h after treatment using PI staining of DNA and FACS analysis. Typical data are shown in B; Error bars represent mean ± S.D. from three independent experiments shown in C.