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. 2010 Apr 28;119(Pt 3):123–129. doi: 10.1042/CS20090640

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A central fat accumulation during pregnancy leads to fatty acid overspill from adipose depots and lipotoxicity. Lipotoxic effects include maternal endothelial dysfunction, decreased trophoblast invasion and altered placental metabolism. These may result in adverse pregnancy outcome (such as pre-eclampsia or miscarriage) and programming of obesity in the offspring. A lower-body fat accumulation allows ‘safe’ storage of fatty acids and a normal metabolic and physiological adaptation to pregnancy with appropriate nutrient transfer to the offspring. TG, triacylglycerol.