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. 2009 Sep 3;85(3):473–483. doi: 10.1093/cvr/cvp305

Figure 2.

Figure 2

Gene expression levels of (A) gp91phox and (B) Nox1 as determined by real-time RT–PCR and western blotting. Both of these genes were significantly upregulated in db/db LV tissue, and PDTC treatment attenuated expression of these genes. Production levels of (C) superoxide, (D) total ROS, and (E) peroxynitrite as determined by EPR spectroscopy. Levels of superoxide, total ROS, and peroxynitrite production were all increased significantly in db/db LV tissue; these levels were normalized with PDTC treatment. (F) Protein expression levels of 3-nitrotyrosine in LV tissues from all experimental groups. *P < 0.05 vs. control; #P < 0.05 vs. db/db; $P < 0.05 vs. db/db PDTC; @P < 0.05 vs. hz PDTC.