Table 1.

Echocardiography data for all experimental groups at study end

Parameter	hz Control	db/db	db/db + PDTC	hz + PDTC
IVSD (mm)	0.65 ± 0.05	0.64 ± 0.04	0.72 ± 0.03	0.78 ± 0.03
IVSS (mm)	1.25 ± 0.06	1.10 ± 0.01	1.12 ± 0.02	1.17 ± 0.04
LVD (mm)	3.70 ± 0.17#	4.89 ± 0.01*,†,‡	4.10 ± 0.07#	4.08 ± 0.08#
LVS (mm)	2.45 ± 0.05#	3.17 ± 0.08*,‡	2.62 ± 0.12	2.58 ± 0.01#
PWD (mm)	0.69 ± 0.02	0.69 ± 0.03	0.74 ± 0.01	0.84 ± 0.04
PWS (mm)	1.12 ± 0.05	1.19 ± 0.02	1.33 ± 0.03	1.26 ± 0.03
FS%	36.11 ± 1.06#	23.69 ± 0.39*,†,‡	35.10 ± 0.31#	34.10 ± 0.20#
HR	437 ± 7.70	420 ± 10.2	437 ± 10.0	431 ± 5.21

Echocardiographic analysis revealed that both left ventricular diastolic (LVD) and systolic (LVS) dimensions were significantly greater and FS% measurements were lower in db/db mice, whereas db/db treated with PDTC and heterozygous lean control mice exhibited significant decreases in LVD, LVS and increases in FS%. Values are expressed as means ± SEM. P < 0.05=significant. Values presented are means ± SEM.

*P < 0.05 vs. control.

^#P < 0.05 vs. db/db.

^†P < 0.05 vs. db/db PDTC.

^‡P < 0.05 vs. hz PDTC.