(c) Pheromone stress
| Target Protein | Literature evidence | Upstream proteins within 40 preselected proteins | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| STE20P,O | [6–8, 23] | STE4 (0.001) | STE3 (0.002) | STE5 (0.008) | CLA4 (0.010) | MSB2 (0.016) | SSK1 (0.016) | STE12 (0.069) | RAS2 (0.080) | CDC24 (0.175) | PTP2 (0.342) | SLT2 (0.471) | CDC42 (0.535) | SHO1 (0.634) |
| HOG1N | [4–8, 23] | STE5 (0.001) | STE4 (0.002) | SSK2 (0.035) | YPD1 (0.099) | MSB2 (0.109) | PTP2 (0.202) | SSK1 (0.235) | FPS1 (0.265) | SHO1 (0.385) | PTC1 (0.393) | SLN1 (0.417) | PTP3 (0.420) | STE11 (0.718) |
| STE4P | [7] | STE5 (0.012) | STE3 (0.019) | STE2 (0.022) | RHO1 (0.036) | STE50 (0.126) | PKC1 (0.128) | STE7 (0.201) | KSS1 (0.231) | STE20 (0.261) | HOG1 (0.365) | STE12 (0.370) | STE11 (0.373) | CDC24 (0.544) |
| STE50P,O | [6–8, 23] | SSK1 (0.011) | STE50 (0.023) | STE5 (0.106) | OPY2 (0.251) | SSK22 (0.318) | SHO1 (0.321) | SSK2 (0.416) | CDC42 (0.539) | STE4 (0.739) | STE11 (0.749) | |||
| SHO1O | [4–8, 23] | PBS2 (0.029) | SSK1 (0.102) | STE11 (0.132) | MSB2 (0.165) | STE50 (0.217) | HKR1 (0.260) | SSK2 (0.263) | HOG1 (0.607) | SHO1 (0.640) | STE20 (0.725) | |||
| SPA2I | [7] | MKK1 (0.070) | STE7 (0.085) | PKC1 (0.162) | CLA4 (0.188) | RAS2 (0.234) | STE11 (0.304) | SSK2 (0.444) | RHO1 (0.609) | SLT2 (0.641) | STE12 (0.672) | |||
| PKC1I | [4, 7, 8] | STE4 (0.010) | PBS2 (0.063) | SLT2 (0.080) | SHO1 (0.187) | BCK1 (0.313) | RHO1 (0.340) | MKK1 (0.365) | PTC1 (0.644) | MID2 (0.819) | ||||
| BEM1P | [4, 24, 32] | STE4 (0.004) | RHO1 (0.009) | STE5 (0.009) | CDC42 (0.033) | CDC24 (0.037) | STE7 (0.045) | CLA4 (0.065) | STE20 (0.245) | STE11 (0.411) | ||||
| STE5P | [7] | STE5 (0.012) | STE4 (0.060) | STE12 (0.151) | HOG1 (0.173) | STE11 (0.230) | CDC24 (0.235) | STE2 (0.303) | STE50 (0.346) | KSS1 (0.560) | ||||
| STE12P,O | [7, 8] | STE4 (0.012) | STE5 (0.016) | STE7 (0.076) | STE12 (0.078) | RAS2 (0.109) | TEC1 (0.180) | STE20 (0.217) | MSB2 (0.431) | STE11 (0.657) | ||||
| PBS2N | [4–8, 23] | SHO1 (0.003) | YPD1 (0.005) | RAS2 (0.010) | PTC1 (0.011) | PKC1 (0.021) | KSS1 (0.022) | SSK2 (0.025) | HOG1 (0.026) | SSK22 (0.029) | ||||
| SSK2N | [4–8, 23] | SSK2 (0.009) | SSK1 (0.034) | PBS2 (0.106) | HOG1 (0.106) | STE50 (0.227) | SHO1 (0.386) | YPD1 (0.431) | FPS1 (0.484) | PTC1 (0.567) | ||||
| PTP2N | [4, 5, 7, 8] | PBS2 (0.039) | MKK1 (0.039) | HOG1 (0.047) | BCK1 (0.150) | PTP3 (0.249) | SSK2 (0.266) | PTC1 (0.288) | SSK1 (0.305) | SLT2 (0.798) | ||||
| CLN2P | [4, 7, 33, 34] | SWI6 (0.001) | STE4 (0.001) | STE11 (0.003) | CLA4 (0.007) | SLT2 (0.009) | CDC42 (0.074) | STE20 (0.096) | RAS2 (0.525) | PKC1 (0.552) | ||||
| NBP2N | [23] | PTP2 (0.021) | STE20 (0.065) | PBS2 (0.120) | HOG1 (0.477) | SSK2 (0.529) | SLT2 (0.567) | BCK1 (0.645) | PTC1 (0.696) | |||||
| BCK1I | [4, 7, 8] | HKR1 (0.003) | MKK1 (0.065) | PTP2 (0.139) | BCK1 (0.164) | SLT2 (0.166) | PKC1 (0.250) | CLA4 (0.267) | MID2 (0.911) | |||||
| KSS1P,O | [6–8] | STE4 (0.022) | STE12 (0.031) | HOG1 (0.179) | STE7 (0.190) | PBS2 (0.237) | TEC1 (0.305) | MSB2 (0.692) | ||||||
| SMI1I | [35, 36] | SLT2 (0.029) | PKC1 (0.236) | CLA4 (0.251) | FPS1 (0.340) | BCK1 (0.380) | PTC1 (0.650) | MID2 (0.790) | ||||||
| FPS1N | [5] | MID2 (0.028) | STE11 (0.047) | SSK22 (0.053) | SSK2 (0.063) | GPD1 (0.202) | SLT2 (0.260) | HOG1 (0.709) | ||||||
| BNI1I | [7, 37, 38] | RHO1 (0.000) | CDC42 (0.000) | STE11 (0.004) | CLA4 (0.005) | STE12 (0.006) | PKC1 (0.009) | BCK1 (0.011) | ||||||
| CLA4O | [5, 6] | MSB2 (0.001) | CDC24 (0.002) | SLT2 (0.003) | BCK1 (0.003) | STE20 (0.006) | STE11 (0.006) | CDC42 (0.007) | ||||||
| PTC1N | [4, 5, 7, 23] | SSK2 (0.070) | PKC1 (0.107) | PTP2 (0.172) | PBS2 (0.342) | HOG1 (0.680) | SLT2 (0.736) | |||||||
| STE7P,O | [6–8] | STE5 (0.012) | STE4 (0.089) | STE12 (0.130) | STE7 (0.331) | STE11 (0.385) | KSS1 (0.568) | |||||||
| SLT2I | [4, 7, 8] | BCK1 (0.001) | PKC1 (0.001) | MID2 (0.003) | FPS1 (0.003) | PTC1 (0.006) | CLA4 (0.007) | |||||||
| FAR1P | [25] | SSK2 (0.008) | STE12 (0.010) | STE5 (0.011) | CDC42 (0.021) | CDC24 (0.029) | STE4 (0.035) | |||||||
| MID2I | [7, 8] | SLT2 (0.019) | MID2 (0.019) | FPS1 (0.065) | MKK1 (0.083) | PKC1 (0.150) | RHO1 (0.166) | |||||||
| FKS1I | [4, 7] | MKK1 (0.009) | SLT2 (0.030) | MID2 (0.050) | RHO1 (0.191) | PKC1 (0.332) | PTC1 (0.414) | |||||||
| SKM1O | [4] | STE3 (0.027) | PTC1 (0.125) | CLA4 (0.131) | SWI6 (0.150) | STE20 (0.197) | CDC42 (0.312) | |||||||
| MKK1I | [4, 7, 8] | BCK1 (0.022) | PTP2 (0.104) | SLT2 (0.196) | PKC1 (0.329) | RHO1 (0.678) | MID2 (0.726) | |||||||
| BEM4I | [31] | PKC1 (0.009) | RHO1 (0.015) | CDC24 (0.018) | CDC42 (0.020) | CLA4 (0.024) | HKR1 (0.027) | |||||||