Table 2.

Selected characteristics of biliary tract cancer cases, stone cases, and controls

							Biliary Tract Cancer (n=411)						Biliary Stones (n=895)

Characteristics	Controls^a		Controls^b		Controls^c		Gallbladder Cancer		Extrahepatic Bile Duct Cancer		Ampulla of Vater Cancer		Gallbladder Stones		Bile Duct Stones

	N	%	N	%	N	%	N	%	N	%	N	%	N	%	N	%

Total	786	100.0	737	100.0	592	100.0	237	100.0	127	100.0	47	100.0	673	100.0	222	100.0
Age
<55	107	13.6	106	14.4	97	16.4	32	13.5	18	14.2	4	8.5	216	32.1^*	53	23.9^*
55–64	224	28.5	216	29.3	169	28.5	62	26.2	32	25.2	9	19.1	186	27.6	66	29.7
>=65	455	57.9	415	56.3	326	55.1	143	60.3	77	60.6	34	72.3	271	40.3	103	46.4
Gender
Male	305	38.8	290	39.3	252	42.6	65	27.4	76	59.8	24	51.1	224	33.3^*	105	47.3
Female	481	61.2	447	60.7	340	57.4	172	72.6	51	40.2	23	48.9	449	66.7	117	52.7
Education
None/Primary	316	40.2	288	39.1	223	37.7	126	53.2	53	41.7	22	46.8	193	28.7^*	78	35.1
Jr. Middle	196	24.9	188	25.5	148	25.0	59	24.9	34	26.8	12	25.5	193	28.7	59	26.6
Sr. Middle	155	19.7	150	20.4	127	21.5	30	12.7	22	17.3	8	17.0	168	25.0	50	22.5
Some college	119	15.1	111	15.1	94	15.9	22	9.3	18	14.2	5	10.6	119	17.7	35	15.8
Marital status
Married	612	77.9	571	77.5	468	79.1	187	78.9	113	89.0	36	76.6	576	85.7^*	189	85.1
Widowed	146	18.6	139	18.9	103	17.4	46	19.4	11	8.7	11	23.4	83	12.4	31	14.0
Divorced/separated	18	2.3	17	2.3	15	2.5	3	1.3	1	0.8	0	0.0	7	1.0	1	0.5
Never married	10	1.3	10	1.4	6	1.0	1	0.4	2	1.6	0	0.0	6	0.9	1	0.5
Smoking (double check)	237	30.2	223	30.3	187	31.6	64	27.1	56	44.1	20	42.6	161	23.9^*	80	36.0
Drinking	162	20.6	151	20.5	134	22.6	36	15.2	42	33.1	12	25.5	101	15.0^*	41	18.6
Diabetes	65	8.3	56	7.6	38	6.4	31	13.1	12	9.4	3	6.4	75	11.1^*	25	11.3^*
Hypertension	336	42.7	309	41.9	237	40.0	87	36.7	37	29.1	13	27.7	229	34.0^*	64	28.8^*
Body mass index
<18.5	66	8.4	65	8.8	55	9.3	11	4.7	6	4.7	1	2.1	25	3.7^*	15	6.8^*
18.5–22.9	325	41.4	313	42.5	268	45.3	79	33.5	57	44.9	20	42.6	229	34.1	74	33.3
23.0–24.9	166	21.1	155	21.1	123	20.8	47	19.9	33	26.0	11	23.4	164	24.4	51	23.0
>=25.0	228	29.0	203	27.6	145	24.5	99	41.9	31	24.4	15	31.9	254	37.8	82	36.9

Chi-square test, p<0.05.

All population controls. Bile duct cancer and ampulla of Vater cancer were compared to all population controls.

Excluded population controls with a history of cholecystectomy (n=49).

Excluded population controls with gallstones (n=145)