Table 2.
Biliary Tract Cancer (n=411) | Biliary Stones (n=895) | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Characteristics | Controlsa | Controlsb | Controlsc | Gallbladder Cancer |
Extrahepatic Bile Duct Cancer |
Ampulla of Vater Cancer |
Gallbladder Stones |
Bile Duct Stones |
||||||||
N | % | N | % | N | % | N | % | N | % | N | % | N | % | N | % | |
Total | 786 | 100.0 | 737 | 100.0 | 592 | 100.0 | 237 | 100.0 | 127 | 100.0 | 47 | 100.0 | 673 | 100.0 | 222 | 100.0 |
Age | ||||||||||||||||
<55 | 107 | 13.6 | 106 | 14.4 | 97 | 16.4 | 32 | 13.5 | 18 | 14.2 | 4 | 8.5 | 216 | 32.1* | 53 | 23.9* |
55–64 | 224 | 28.5 | 216 | 29.3 | 169 | 28.5 | 62 | 26.2 | 32 | 25.2 | 9 | 19.1 | 186 | 27.6 | 66 | 29.7 |
>=65 | 455 | 57.9 | 415 | 56.3 | 326 | 55.1 | 143 | 60.3 | 77 | 60.6 | 34 | 72.3 | 271 | 40.3 | 103 | 46.4 |
Gender | ||||||||||||||||
Male | 305 | 38.8 | 290 | 39.3 | 252 | 42.6 | 65 | 27.4 | 76 | 59.8 | 24 | 51.1 | 224 | 33.3* | 105 | 47.3 |
Female | 481 | 61.2 | 447 | 60.7 | 340 | 57.4 | 172 | 72.6 | 51 | 40.2 | 23 | 48.9 | 449 | 66.7 | 117 | 52.7 |
Education | ||||||||||||||||
None/Primary | 316 | 40.2 | 288 | 39.1 | 223 | 37.7 | 126 | 53.2 | 53 | 41.7 | 22 | 46.8 | 193 | 28.7* | 78 | 35.1 |
Jr. Middle | 196 | 24.9 | 188 | 25.5 | 148 | 25.0 | 59 | 24.9 | 34 | 26.8 | 12 | 25.5 | 193 | 28.7 | 59 | 26.6 |
Sr. Middle | 155 | 19.7 | 150 | 20.4 | 127 | 21.5 | 30 | 12.7 | 22 | 17.3 | 8 | 17.0 | 168 | 25.0 | 50 | 22.5 |
Some college | 119 | 15.1 | 111 | 15.1 | 94 | 15.9 | 22 | 9.3 | 18 | 14.2 | 5 | 10.6 | 119 | 17.7 | 35 | 15.8 |
Marital status | ||||||||||||||||
Married | 612 | 77.9 | 571 | 77.5 | 468 | 79.1 | 187 | 78.9 | 113 | 89.0 | 36 | 76.6 | 576 | 85.7* | 189 | 85.1 |
Widowed | 146 | 18.6 | 139 | 18.9 | 103 | 17.4 | 46 | 19.4 | 11 | 8.7 | 11 | 23.4 | 83 | 12.4 | 31 | 14.0 |
Divorced/separated | 18 | 2.3 | 17 | 2.3 | 15 | 2.5 | 3 | 1.3 | 1 | 0.8 | 0 | 0.0 | 7 | 1.0 | 1 | 0.5 |
Never married | 10 | 1.3 | 10 | 1.4 | 6 | 1.0 | 1 | 0.4 | 2 | 1.6 | 0 | 0.0 | 6 | 0.9 | 1 | 0.5 |
Smoking (double check) | 237 | 30.2 | 223 | 30.3 | 187 | 31.6 | 64 | 27.1 | 56 | 44.1 | 20 | 42.6 | 161 | 23.9* | 80 | 36.0 |
Drinking | 162 | 20.6 | 151 | 20.5 | 134 | 22.6 | 36 | 15.2 | 42 | 33.1 | 12 | 25.5 | 101 | 15.0* | 41 | 18.6 |
Diabetes | 65 | 8.3 | 56 | 7.6 | 38 | 6.4 | 31 | 13.1 | 12 | 9.4 | 3 | 6.4 | 75 | 11.1* | 25 | 11.3* |
Hypertension | 336 | 42.7 | 309 | 41.9 | 237 | 40.0 | 87 | 36.7 | 37 | 29.1 | 13 | 27.7 | 229 | 34.0* | 64 | 28.8* |
Body mass index | ||||||||||||||||
<18.5 | 66 | 8.4 | 65 | 8.8 | 55 | 9.3 | 11 | 4.7 | 6 | 4.7 | 1 | 2.1 | 25 | 3.7* | 15 | 6.8* |
18.5–22.9 | 325 | 41.4 | 313 | 42.5 | 268 | 45.3 | 79 | 33.5 | 57 | 44.9 | 20 | 42.6 | 229 | 34.1 | 74 | 33.3 |
23.0–24.9 | 166 | 21.1 | 155 | 21.1 | 123 | 20.8 | 47 | 19.9 | 33 | 26.0 | 11 | 23.4 | 164 | 24.4 | 51 | 23.0 |
>=25.0 | 228 | 29.0 | 203 | 27.6 | 145 | 24.5 | 99 | 41.9 | 31 | 24.4 | 15 | 31.9 | 254 | 37.8 | 82 | 36.9 |
Chi-square test, p<0.05.
All population controls. Bile duct cancer and ampulla of Vater cancer were compared to all population controls.
Excluded population controls with a history of cholecystectomy (n=49).
Excluded population controls with gallstones (n=145)