Table 3.

Odds ratios (ORs) and 95% confidence intervals (CIs) for biliary stones in relation to selected variants in inflammation genes

		Biliary Stones				Gallstones				Bile Duct Stones
Gene/SNP (dbSNP ID)	Controls	Cases	ORa	95% CI	P- rend	Cases	ORa	95% CI	P trend	Cases	ORa	95% CI	P trendb
Total	592	883				664				219
IL8
−351A>T (rs4073)
TT	181	295	1.00	-		196	1.00	-		99	1.00	-
TA	317	439	0.86	0.68–1.09		358	1.06	0.82–1.37		81	0.48	0.34–0.68
AA	89	149	1.02	0.74–1.42		110	1.14	0.80–1.63		39	0.80	0.51–1.26
					0.82				0.45				0.04
TA or AA	406	588	0.90	0.71–1.12		468	1.08	0.84–1.38		120	0.55	0.40–0.76
IVS1+230 T>G (rs2227307)
TT	180	296	1.00	-		196	1.00	-		100	1.00	-
TG	317	437	0.85	0.67–1.08		355	1.04	0.81–1.35		82	0.48	0.34–0.68
GG	87	148	1.03	0.75–1.44		110	1.17	0.82–1.66		38	0.79	0.50–1.25
					0.83				0.42				0.03
TG/GG	404	585	0.89	0.71–1.12		465	1.07	0.83–1.37		120	0.55	0.40–0.76
IVS1-204C>T(rs2227306)
CC	213	351	1.00	-		239	1.00	-		112	1.00	-
CT	305	423	0.84	0.67–1.06		345	1.01	0.79–1.30		78	0.50	0.35–0.70
TT	70	121	1.03	0.73–1.46		89	1.11	0.77–1.61		32	0.87	0.54–1.41
					0.65				0.64				0.03
CT or TT	375	544	0.88	0.71–1.09		434	1.03	0.82–1.31		110	0.57	0.42–0.78
Global P valueb					0.83				0.64				0.04
IL8RB
Ex3+811C<T (rs2230054)
CC	282	357	1.00	-		270	1.00	-		87	1.00	-
CT	223	373	1.34	1.06–1.69		277	1.33	1.03–1.70		96	1.41	1.00–1.98
TT	54	107	1.65	1.14–2.38		82	1.70	1.15–2.52		25	1.50	0.88–2.56
					0.002				0.002				0.04
CT or TT	277	480	1.40	1.13–1.74		359	1.40	1.10–1.77		121	1.42	1.03–1.97
Ex3+1235T<C (rs1126579)
TT	247	325	1.00	-		246	1.00	-		79	1.00	-
TC	255	396	1.17	0.93–1.48		294	1.15	0.90–1.47		102	1.24	0.88–1.75
CC	65	125	1.53	1.08–2.17		97	1.60	1.11–2.32		28	1.35	0.81–2.26
					0.01				0.02				0.16
TC or CC	320	521	1.25	1.00–1.55		391	1.24	0.98–1.57		130	1.26	0.91–1.75
Ex3-1010G<A (rs1126580)
GG	339	463	1.00	-		354	1.00	-		109	1.00	-
GA	196	336	1.27	1.01–1.59		248	1.22	0.95–1.56		88	1.41	1.01–1.97
AA	30	44	1.09	0.67–1.78		35	1.17	0.69–1.97		9	0.89	0.41–1.95
					0.11				0.15				0.22
GA/AA	226	380	1.24	1.00–1.55		283	1.21	0.96–1.53		97	1.34	0.97–1.85
Global P value					0.006				0.006				0.12
RNASEL
Ex1-96 A>G (rs486907)
GG	357	488	1.00	-		355	1.00	-		133	1.00	-
GA	204	348	1.22	0.98–1.53		270	1.34	1.05–1.70		78	1.01	0.72–1.40
AA	28	53	1.37	0.84–2.23		43	1.52	0.91–2.53		10	0.93	0.44–1.97
					0.05				0.001				0.92
GA/AA	232	401	1.24			313	1.36	1.08–1.71		88	1.00	0.72–1.37
Ex6-560A>G (rs11072)
TT	356	563	1.00	-		419	1.00	-		144	1.00	-
TC	186	253	0.86	0.68–1.09		189	0.87	0.67–1.12		64	0.85	0.60–1.20
CC	24	31	0.78	0.45–1.36		25	0.84	0.47–1.52		6	0.59	0.23–1.47
					0.16				0.25				0.18
TC/CC	210	284	0.85	0.68–1.07		214	0.86	0.68–1.10		70	0.82	0.59–1.15
Global P value					0.10				0.002				0.36
TNF
−1211C>T (rs1799964)
TT	360	562	1.00	-		432	1.00	-		130	1.00	-
TC	183	269	0.96	0.76–1.21		194	0.91	0.71–1.17		75	1.14	0.81–1.60
CC	29	32	0.70	0.41–1.19		23	0.64	0.36–1.14		9	0.88	0.40–1.92
					0.28				0.15				0.74
TC or CC	212	301	0.92	0.74–1.15		217	0.87	0.68–1.11		84	1.10	0.80–1.53
−1042A>C (rs1800630)
CC	382	621	1.00	-		479	1.00	-		142	1.00	-
CA	163	210	0.81	0.64–1.04		146	0.74	0.57–0.97		64	1.05	0.74–1.49
AA	20	19	0.59	0.31–1.13		14	0.54	0.27–1.10		5	0.68	0.25–1.86
					0.03				0.0008				0.83
CA or AA	183	229	0.79	0.62–1.00		160	0.72	0.56–0.93		69	1.01	0.72–1.42
−1036C>T (rs1799724)
CC	439	659	1.00	-		491	1.00	-		168	1.00	-
CT	139	208	0.97	0.76–1.25		161	1.00	0.76–1.30		47	0.90	0.62–1.31
TT	9	19	1.23	0.54–2.78		13	1.10	0.46–2.65		6	1.60	0.56–4.60
					0.94				0.93				0.99
CT/TT	148	227	0.99	0.78–1.26		174	1.01	0.77–1.30		53	0.94	0.66–1.36
−487A>G (rs1800629)
GG	510	772	1.00	-		582	1.00	-		190	1.00	-
GA	66	102	1.05	0.75–1.46		78	1.06	0.74–1.51		24	0.97	0.59–1.60
AA	6	3	-	-		2	-	-		1	-	-
					0.67				0.76				0.64
GA or AA	72	105	0.99	0.71–1.37		80	1.00	0.71–1.42		25	0.93	0.57–1.51
−417A>G (rs361525)
GG	551	820	1.00	-		614	1.00	-		206	1.00	-
GA	37	68	1.21	0.79–1.84		53	1.28	0.82–1.99		15	1.13	0.60–2.11
AA	0	4	-	-		3	-	-		1	-	-
					0.17				0.11				0.46
GA or AA	37	72	1.28	0.84–1.94		56	1.36	0.87–2.10		16	1.19	0.65–2.21
IVS1+123G>A (rs1800610)
GG	395	597	1.00	-		448	1.00	-		149	1.00	-
GA	164	225	0.88	0.69–1.12		169	0.86	0.67–1.12		56	0.92	0.64–1.31
AA	12	25	1.27	0.62–2.58		19	1.27	0.60–2.68		6	1.28	0.47–3.50
					0.63				0.58				0.89
GA or AA	176	250	0.91	0.72–1.15		188	0.89	0.69–1.15		62	0.94	0.67–1.34
Global P value					0.18				0.30				0.99
NOS2
IVS20+524G>A (rs944722)
AA	328	435	1.00	-		291	1.00	-		107	1.00	-
AG	263	358	1.04	0.83–1.31		232	1.02	0.80–1.30		95	1.10	0.79–1.52
GG	50	62	0.91	0.60–1.37		47	0.94	0.61–1.46		12	0.72	0.37–1.41
					0.92				0.91				0.77
AG or GG	313	420	1.02	0.82–1.26		279	1.00	0.80–1.26		107	1.04	0.76–1.42
Ex16+14C>T (rs2297518)
CC	427	582	1.00	-		412	1.00	-		155	1.00	-
CT	198	249	1.32	1.03–1.69		138	1.47	1.13–1.91		51	1.00	0.69–1.45
TT	14	20	1.16	0.56–2.38		13	1.12	0.51–2.45		6	1.29	0.48–3.48
					0.05				0.01				0.80
CT or TT	212	269	1.30	1.03–1.66		151	1.44	1.11–1.85		57	1.02	0.71–1.46
Global P value					0.10				0.02				0.80

^aAdjusted for age and gender.

^bP value for global test to assess the overall gene effect.