Table 4.

Odds ratios (ORs) and 95% confidence intervals (CIs) for biliary tract cancers in relation to selected variants in inflammation genes

	Gallbladder Cancer					Extrahepatic Bile Duct Cancer					ampulla of Vater Cancer

Gene/SNP (dbSNP ID)	Cases	Controls	OR^a	95% CI	P- trend	Cases	Controls	OR	95% CI	P-trend	Cases	Controls	OR^a	95% CI	P- trend
Total	237	737	-	-	-	127	786	-	-	-	47	786	-	-	-

*IL10*

Ex5+210C>T (rs3024496)
TT	223	678	1.00	-		116	720	1.00	-		40	720	1.00	-
TC	12	51	0.74	0.38–1.41		9	57	0.95	0.45–1.98		7	57	2.12	0.90–5.00
CC	0	1	-	-		0	1	-	-		0	1	-	-
					0.30					0.84					0.10
TC or CC	12	52	0.72	0.38–1.38		9	58	0.94	0.45–1.96		7	58	2.10	0.89–4.96
IVS1-286G>T (rs3024491)
GG	225	683	1.00	-		118	726	1.00	-		40	726	1.00	-
GT	11	50	0.69	0.35–1.35		9	56	0.95	0.46–2.00		7	56	2.16	0.92–5.11
TT	0	1	-	-		0	1	-	-		0	1	-	-
					0.23					0.85					0.09
GT or TT	11	51	0.67	0.34–1.32		9	57	0.94	0.45–1.98		7	57	2.14	0.91–5.06
−6653A>C (rs1800872)
AA	121	318	1.00	-		57	340	1.00	-		19	340	1.00	-
AC	91	334	0.70	0.51–0.96		16	90	0.93	0.62–1.41		21	90	1.13	0.60–2.15
CC	23	82	0.76	0.45–1.26		52	352	1.09	0.59–2.01		6	352	1.26	0.49–3.26
					0.06					0.94					0.60
AC or CC	114	416	0.71	0.53–0.96		68	442	0.97	0.66–1.42		27	442	1.16	0.63–2.13
−7334T>C (rs1800871)
TT	122	311	1.00	-		55	334	1.00	-		20	334	1.00	-
TC	92	335	0.69	0.50–0.94		52	353	0.94	0.62–1.42		6	353	1.06	0.56–2.00
CC	23	82	0.74	0.44–1.23		17	90	1.19	0.65–2.16		21	90	1.19	0.46–3.07
					0.04					0.76					0.73
TC or CC	115	417	0.70	0.52–0.94		69	443	0.99	0.67–1.46		27	443	1.09	0.60–1.98
−1116A>G (rs1800896)
AA	231	624	1.00	-		107	664	1.00	-		38	664	1.00	-
AG	23	99	0.65	0.40–1.06		18	108	1.11	0.65–1.93		9	108	1.50	0.70–3.21
GG	1	7	-	-		0	7	-	-		0	7	-	-
					0.06					0.91					0.51
AG or GG	24	106	0.63	0.40–1.03		18	115	1.04	0.60–1.80		9	115	1.41	0.66–3.00
*Global p value*					0.10					0.94					0.25

*VEGF*

236bp 3’ of STP (rs3025039)
CC	172	487	1.00	-		87	518	1.00	-		32	518	1.00
CT	58	21	0.72	0.51–1.01		34	236	0.87	0.56–1.34		15	236	1.03	0.55–1.94
TT	4	22	-	-		5	25	1.20	0.44–3.28		0	25	-
					0.03					0.78					0.55
CT or TT	62	43	0.70	0.50–0.97		39	261	0.90	0.60–1.36		15	261	0.93	0.49–1.75

Adjusted for age and gender.

P value for global test to assess the overall gene effect.