Table 5.
Odds ratios (OR)a and 95% confidence intervals (CI) for biliary tract cancer and biliary stones in relation to common haplotypes
| Gene/Haplotype | Controls | Biliary Tract Cancer | Biliary Stones | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gallbladder | Bile Duct | ampulla of Vater | Gallstones | Bile Duct Stones | ||||||||||||
| % | % | ORa | 95% CI | % | ORa | 95% CI | % | ORa | 95% CI | % | ORa | 95% CI | % | ORa | 95% CI | |
| IL8RBb | ||||||||||||||||
| C-T-G | 64.4 | 62.4 | 1.00 | - | 61.0 | 1.00 | - | 62.9 | 1.00 | - | 61.5 | 1.00 | - | 61.0 | 1.00 | - |
| T-C-A | 23.0 | 23.7 | 1.09 | (0.83–1.37) | 24.9 | 1.05 | (0.75–1.46) | 22.2 | 0.94 | (0.56–1.58) | 24.2 | 1.20 | (0.98–1.46) | 25.9 | 1.25 | (0.96–1.64) |
| T-C-G | 8.3 | 9.6 | 1.16 | (0.79–1.70) | 6.0 | 0.75 | (0.41–1.39) | 11.4 | 1.42 | (0.69–2.90) | 10.4 | 1.54 | (1.14–2.07) | 8.7 | 1.25 | (0.81–1.92) |
| C-C-G | 2.9 | 3.8 | 1.36 | (0.75–2.47) | 3.8 | 1.27 | (0.59–2.75) | -- | -- | -- | 3.1 | 1.04 | (0.64–1.68) | 2.3 | 0.79 | (0.37–1.68) |
| C-C-A | 1.2 | 0.5 | -- | -- | 1.5 | 1.42 | (0.42–4.74) | -- | -- | -- | 0.7 | -- | -- | 1.4 | 1.29 | (0.45–3.70) |
| Global p-value | 0.40 | 0.003 | 0.80 | 0.02 | 0.32 | |||||||||||
a
Adjusted for age and gender.
b
IL8RB SNPs: Ex3+811C>T, Ex3+1235T>C, Ex3-1010G>A.