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TAM and BDMC activation during urethane-induced tumorigenesis in IFN-γ-/- and IL-4Rα-/- mice. Tumor-associated BAL macrophages (F4/80): green, BDMCs (BM. CD-68): green, arginase I: blue, iNOS: red, 32 weeks after the first urethane injection in (A) wild-type controls, (B) IFN-γ-/- mice and (C) IL-4Rα-/- mice. Co-localization of F4/80 and iNOS or arginase I indicates that the cells staining for iNOS and arginase I are indeed macrophages. Final magnification 630×.
