Figure 3.
The presence of TIMs in IL-4Rα-/- and IFN-γ-/- mice. (A) Macrophages (F4/80) stained dark brown in uninvolved lung tissue adjacent to tumors (TAMs, right column) and within the tumor parenchyma (TIMs, left column) at 32 weeks after urethane induction. Final magnification 400×. (B) TIMs at 32 weeks. **p<0.001 compared to wild-type and IFN-γ-/- mice. Data represents the mean ± SEM. (C) iNOS immunohistochemical staining in TIMs (circled) 32 weeks after urethane treatment in IL-4Rα-/- mice.