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. Author manuscript; available in PMC: 2010 Apr 28.
Published in final edited form as: Nat Genet. 2003 Aug 17;35(1):84–89. doi: 10.1038/ng1229

Figure 3.

Figure 3

Destabilization of the dysbindin, pallidin and muted proteins in extracts of three HPS mutants (sdy, pa and mu). We separated kidney extracts from 16 mouse HPS or HPS-related mutants and 4 control strains (DBA/2J, mu/+, C57BL/6J and C3H/HeJ) on denaturing gels and probed them with antibodies to dysbindin, muted and pallidin as indicated at left. Dystrobrevins were similarly analyzed in the brain as expression of α-dystrobrevin is weak in kidney. Inbred strain DBA/2J served as the control for sdy/sdy, mu/+ for mu/mu, C3H/HeJ for sut/sut, ash/ash and ru6J/ru6J and C57BL/6J for the remaining mutants. Antibodies to Rab4 and α-tubulin served as loading controls.