Table 3.
Summary of log-linear modeling results for case-parent triads based on full group
| MTHFR A1298C |
MTHFR C677T |
MS/MTR A2756G |
MTRR A66G |
MCP1 (-A2518G) |
BHMT G742A |
TCN2 C777G |
SHMT C1420T |
NOS3 G894T |
|
|---|---|---|---|---|---|---|---|---|---|
| Trios/Dyads/Mono(N) | 235/80/12 | 239/75/13 | 228/84/14 | 224/83/17 | 226/88/13 | 234/79/14 | 217/89/20 | 231/81/16 | 232/86/10 |
| General Model | |||||||||
| 1.06 | 1.08 | 0.89 | 1.14 | 0.88 | 0.91 | 0.69 | 1.12 | 0.88 | |
| R1 (95% CI) | (0.77–1.45) | (0.78–1.50) | (0.65–1.24) | (0.77–1.69) | (0.64–1.20) | (0.67–1.25) | (0.49–0.98) | (0.81–1.54) | (0.65–1.20) |
| 1.28 | 1.18 | 1.75 | 1.09 | 0.98 | 0.50 | 0.65 | 1.10 | 1.22 | |
| R2 (95% CI) | (0.73–2.25) | (0.70–2.01) | (0.85–3.59) | (0.67–1.79) | (0.51–1.89) | (0.27–0.93) | (0.38–1.09) | (0.60–2.00) | (0.71–2.10) |
| 1.14 | 1.01 | 1.03 | 0.96 | 0.83 | 1.17 | 0.81 | 1.17 | ||
| S1 (95% CI) | (0.81–1.60) | (0.70–1.44) | NA | (0.66–1.61) | (0.69–1.35) | (0.57–1.20) | (0.80–1.71) | (0.57–1.16) | (0.83–1.64) |
| 1.09 | 1.18 | 0.66 * | 0.95 | 0.96 | 0.90 | 0.83 | 1.07 | 1.33 | |
| S2 (95% CI) | (0.59–2.01) | (0.66–2.09) | (0.48–0.93) | (0.59–1.53) | (0.50–1.83) | (0.47–1.70) | (0.51–1.34) | (0.55–2.07) | (0.75–2.37) |
| LRT (2df) for offspring effects (p value) | 0.75 (0.69) | 0.42 (0.81) | 3.75 (0.15) | 0.45 (0.80) | 0.75 (0.69) | 5.49 (0.06) | 4.04 (0.13) | 0.45 (0.80) | 2.03 (0.36) |
| LRT (2df) for maternal effects (p value) | 0.57 (0.75) | 0.33 (0.85) | 5.95 * (0.01) | 0.16 (0.92) | 0.06 (0.97) | 1.00 (0.61) | 1.68 (0.43) | 1.49 (0.48) | 1.52 (0.47) |
*
Estimated by dominant model in which S1=S2.