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. Author manuscript; available in PMC: 2010 Apr 28.
Published in final edited form as: J Immunol. 2009 May 15;182(10):5949–5959. doi: 10.4049/jimmunol.0802830

Figure 10.

Figure 10

Induction of early CXCL1 and CXCL2 during elicitation of CHS requires IFN-γ and IL-17. (A) On day +5, groups of DNFB-sensitized C57BL/6 mice were treated with 250 μg rat IgG, anti-IFN-γ, or anti-IL-17 i.p. just prior to hapten challenge. (B and C) Groups of 4 wild-type BALB/c, IFN-γ−/− and IL-17−/− mice were sensitized with 0.25% DNFB on days 0 and +1. Challenged skin was excised at 6 hrs. post-challenge and prepared tissue homogenates tested for levels of (A and B) CXCL1 and (C) CXCL2 by ELISA. The mean chemokine concentration ± SEM for 4 individual mice is shown. Results are representative of two individual experiments. *p < 0.03.