Table 1.
Dual luciferase results of each APOH promoter construct in COS−1 cells
| SNPs | Wildtype Allele (Mean ± SD) |
Variant Allele (Mean ± SD) |
% Decrease | P −value |
|---|---|---|---|---|
|
−1284C>G |
C 5.06 ± 0.10 5.27 ± 0.06 5.55 ± 0.46 |
G 4.16 ± 0.36 4.56 ± 0.34 4.64 ± 0.46 |
17.79 13.47 16.40 |
0.014 0.023 0.075 |
|
−1219G>A |
G 2.86 ± 0.05 4.10 ± 0.21 3.70 ± 0.12 |
A 1.40 ± 0.01 2.06 ± 0.16 1.81 ± 0.08 |
51.05 49.76 51.08 |
< 0.001 < 0.001 < 0.001 |
|
−1190G>C |
G 3.01 ± 0.19 2.79 ± 0.19 3.93 ± 0.50 |
C 2.16 ± 0.03 1.98 ± 0.23 2.84 ± 0.08 |
28.24 29.03 27.74 |
< 0.01 < 0.01 < 0.01 |
|
−1076G>A |
G 10.01 ± 0.38 10.86 ± 0.53 8.40 ± 0.47 |
A 9.13 ± 0.86 9.98 ± 0.60 7.74 ± 0.07 |
8.79 8.10 7.86 |
0.178 0.129 0.075 |
|
−1055T>G |
T 4.66 ± 0.18 7.66 ± 0.53 3.49 ± 0.09 |
G 3.44 ± 0.17 6.13 ± 0.04 2.53 ± 0.14 |
26.18 19.97 27.51 |
< 0.01 < 0.01 < 0.01 |
|
−759A>G |
A 5.28 ± 0.29 4.82 ± 0.27 4.90 ± 0.12 |
G 4.57 ± 0.11 4.27 ± 0.18 4.38 ± 0.50 |
13.45 11.41 10.61 |
0.017 0.042 0.155 |
|
−700C>A |
C 4.65 ± 0.05 4.90 ± 0.17 4.27 ± 1.32 |
A 4.31 ± 0.10 4.58 ± 0.33 3.99 ± 0.51 |
7.31 6.53 6.56 |
< 0.01 0.214 0.745 |
|
−643T>C |
T 19.91 ± 1.68 5.73 ± 0.07 10.79 ± 0.88 |
C 11.94 ± 0.15 3.20 ± 0.24 6.26 ± 0.39 |
40.03 44.15 41.98 |
0.001 < 0.001 0.002 |
|
−627A>C |
A 3.09 ± 0.15 6.72 ± 0.31 5.75 ± 0.23 |
C 2.85 ± 0.11 6.18 ± 0.12 5.12 ± 0.01 |
7.77 8.04 10.96 |
0.086 0.049 0.009 |
|
−363 C>T |
C 3.82 ± 0.34 2.96 ± 0.49 2.88 ± 0.16 |
T 3.34 ± 0.25 2.42 ± 0.40 2.44 ± 0.26 |
12.57 18.24 15.28 |
0.117 0.212 0.065 |
|
−38G>A |
G 4.56 ± 0.15 3.95 ± 0.20 3.81 ± 0.09 |
A 3.62 ± 0.15 3.21 ± 0.17 3.16 ± 0.03 |
20.61 18.73 17.06 |
0.002 0.009 < 0.001 |
|
−32C>A |
C 18.91 ± 0.38 15.79 ± 1.03 16.71 ± 0.92 |
A 11.92 ± 0.39 10.32 ± 0.17 10.56 ± 0.06 |
36.96 34.64 36.8 |
< 0.001 < 0.001 < 0.001 |