Table 2.

Serous tubal intraepithelial carcinoma in pelvic serous carcinoma cases.

Author	Study design	Study population	Sectioning Protocol	Findings
Salvador et al. 2008 [28]	Cross-sectional	16 cases of epithelial ovarian malignancy with tubes submitted in toto	fallopian tubes submitted in toto and serially sectioned every 3-4 mm	10 of the 12 cases of high-grade serous carcinoma showed either unilateral tubal mucosal involvement by TIC (n = 7) or tubal obliteration ipsilateral to the dominant ovarian mass (n = 3). In 3 of 5 selected high grade serous carcinoma cases with TICs, FISH analysis showed similar copy number changes in foci of the ovarian and fallopian tube mucosal carcinoma; one case was not synchronous and the 5th was indeterminate
Kindelberger et al. 2007 [27]	Cross-sectional	55 cases containing pelvic serous carcinoma (mean age 61.5, range 43–82)	SEE-FIM for all cases	41(75%) showed involvement of endosalpinx; 11 were classified as tubal or peritoneal primary; (9 of these had TICs); 20/30 cases classified as ovarian had TICs; 93% of TICs involved the fimbria. Of 5 ovarian cases with TICs, p53 DNA analysis showed identical mutations in at least one focus of TIC and ovarian cancer
Carlson et al. 2008 [29]	Cross-sectional	45 cases of primary peritoneal serous carcinoma in which there was either nonuniform sampling of the fallopian tube (n = 26) or SEE-FIM protocol (n = 19)	nonuniform sampling (portion of tube submitted), or SEE-FIM protocol	9 (35%) of first sampling group and 9 (47%) of second samping group showed STICs. 5/5 cases tested showed identical p53 mutations in the peritoneal and tubal lesions

FISH: fluorescence in situ hybridization; SEE-FIM: sectioning and extensively examining the fimbriae; STIC: serous tubal intraepithelial carcinoma; TIC: tubal intraepithelial carcinoma.