Fig. 1.

Following pneumonectomy, neointima and smooth muscle hypertrophy are observed after MCT treatment. The panels show rat lung tissues stained with trichrome elastin. Lung tissues from rats treated with vehicle (left), MCT following pneumonectomy (centre) and MCT following a sham operation (right) are shown at low magnification. Bar, 250 μm (upper panels). The lower panels are higher magnification views (×40) of the vessels that are indicated by arrows in the upper panels. Note the extensive neointimal formation in the MCT following pneumonectomy panel only; smooth muscle hypertrophy is observed in both of the MCT-treated rats. Figure used with permission from The American Physiological Society (White et al., 2007).