Table 3.

Regulation of Irs1, Mt1 and Igfals in kidney by growth hormone (GH) and/or calorie restriction (CR). The tables lists p-values generated from an analysis of variance applied to the expression data shown in Figure 3. The analysis of variance included three factors, including genotype (Prop1(df/df) or wild-type), diet (CR or ad lib) and treatment (GH or saline injection). For each of the three genes examined, the three-way interaction between genotype, diet and treatment was non-significant, and was therefore excluded from each model. Significant p-values are shown in bold-faced type.

Effect	P-value (Irs1)	P-Value (Mt1)	P-Value (Igfals)
Genotype (G)	< 0.001	< 0.001	< 0.001
Diet (D)	0.007	0.907	0.219
Treatment (T)	0.430	0.275	0.525
G*D	0.208	0.019	0.654
G*T	0.096	0.020	0.001
D*T	0.319	0.236	0.708