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. 2010 Feb 16;19(10):1930–1938. doi: 10.1093/hmg/ddq068

Figure 1.

Figure 1.

Enhancement of human tau-induced retinal degeneration by overexpression of Drosophila Chk2. (A) Eye size is normal in a control fly with the pan-retinal gmr-GAL4 driver only. (B) Expression of human tau in the eye reduces eye size. (C) Flies co-expressing tau and Chk2 have smaller eyes than flies expressing tau alone. (D) Expression of Chk2 alone does not change eye size. (E) Expression of expanded polyglutamine repeat peptides (108 polyQ repeat peptides) in the eye causes depigmentation. (F) Expression of Chk2 does not enhance eye phenotype induced by expanded polyglutamine repeat peptides. (G) Expression of two copies of Alzheimer's amyloid β 42 peptides with Arctic mutation (50) in the eye causes degeneration. (H) Expression of Chk2 does not enhance eye degeneration induced by Alzheimer's amyloid-β 42 peptides with Arctic mutation.