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. 2010 Feb 16;19(10):1930–1938. doi: 10.1093/hmg/ddq068

Figure 3.

Figure 3.

The S262A tau mutation greatly reduces tau toxicity and abolishes Chk2-induced enhancement of tau toxicity. (A) Establishment of transgenic flies expressing human 0N4Rtau with the S262A mutation in fly eyes with the pan-retinal gmr-GAL4 driver. Western blot of head lysates with anti-human tau show that human wild-type tau and human S262A tau are expressed at similar levels in the transgenic flies. (B–E) External eyes of flies carrying the gmr-GAL4 driver only (B), expressing wild-type human tau (C), expressing S262A tau (D) or flies co-expressing S262A tau and Drosophila Chk2 (E).