Table 2.

Defined functions for protein phosphorylation

Effect of phosphorylation on protein function	Residuesa	Proteinsb
Specific effects on protein structure/function
Promotes a protein interaction	184	35
Inhibits a protein interaction	93	18
Modifies interaction with small  molecule/ligand	11	6
Functional consequence of phosphorylation
Activates protein function	209	88
Inhibits protein function	90	17
Targets protein for degradation	48	17
Enhances protein stability	19	4
Modifies subcellular localization	37	15

^aNumber of individual phosphorylated residues in PhosphoGRID assigned the indicated function.

^bNumber of proteins in PhosphoGRID bearing a phosphoresidue assigned the indicated function.