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. 2010 Apr 1;120(5):1708–1721. doi: 10.1172/JCI40794

Figure 6. The large intestine of mutant mice shows shorter glands.

Figure 6

Sections of adult wild-type (A and C) and mutant (B and D) large intestine were examined for their overall appearance (A and B) and the presence of goblet cells (C and D). (A and B) H&E staining clearly shows the reduction in the length of the glands in the large intestine of mutant mice (B, measurement in E) compared with control tissue. (C and D) Periodic acid–Schiff staining of goblet cells. (E) The colonic glands in mutant animals are on average 26% shorter than the colonic glands of control animals (n = 4; 50–60 glands were analyzed per genotype). **P < 0.01. The age of the animals analyzed is 10–12 weeks.