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. 2010 Apr 1;120(5):1708–1721. doi: 10.1172/JCI40794

Figure 8. Strong reduction of the intestinal absorptive surface area but normal expression of brush border enzymes and glucose transporters in Ngn3-deficient mice.

Figure 8

Sections of control (A, C, E, G, and I) and mutant (B, D, F, H, and J) intestine were examined for the status of the absorptive cell population. Analyses of the lactase activity (A and B) and immunofluorescence staining for sucrase-isomaltase (C and D), the active glucose transporter Glut2 (E and F), and the passive glucose transporter SGLT1 (G and H) did not show any difference between control and mutant tissue, respectively. (I and J) Ultrastructural analysis of the brush border of the absorptive cells demonstrates a strong reduction of the microvilli length in mutant mice. The dashed lines in A and B indicate the bottom of the crypt compartment. The age of the mice analyzed in A and B is P1.5 and in C–J is 10–12 weeks. Original magnification, ×20 (A–H); ×40,000 (I and J).