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. 2010 Apr 19;120(5):1506–1514. doi: 10.1172/JCI40096

Figure 1. Upregulation of cardiac insulin signals by pressure overload.

Figure 1

(A) Mice were subjected to TAC or sham operation (sham), and heart samples were obtained 2 weeks later. Mice were starved for 6 hours, and insulin or PBS was injected before sacrifice. pIrs1 and pAkt levels in the heart were examined by Western blot analysis. The graphs indicate relative expression levels of pIrs1 and pAkt. n = 3. TAC2w, 2 weeks after TAC. (B) Mice were subjected to TAC or sham operation and were sacrificed 2 weeks later. Components of the insulin signaling pathway in the heart were examined by Western blot analysis. The graphs indicate relative expression levels of these signaling molecules. n = 3. Data are shown as mean ± SEM. *P < 0.05; **P < 0.01.