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. 2010 Apr 19;120(5):1506–1514. doi: 10.1172/JCI40096

Figure 2. Depletion of plasma insulin attenuates systolic dysfunction induced by pressure overload.

Figure 2

(A) STZ- or vehicle-treated mice were subjected to TAC or sham operation. The heart weight/body weight (HW/BW) ratio was measured 2 weeks after operation. In the insulin-treated group, daily i.p. injection of insulin (0.1 IU/g/d) was performed from 9 weeks (2 weeks after STZ treatment) to 13 weeks of age (2 weeks after TAC). n = 22–24. (B) Cardiac hypertrophy and systolic function of the animals prepared for A were estimated by echocardiography at 1 week (IVST) or 2 weeks (FS and LVDs) after operation. Photographs show representative results of echocardiography (M-mode). n = 6–10. Data are shown as mean ± SEM. *P < 0.05; **P < 0.01. IVST, intraventricular septal thickness; FS, fractional shortening.