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. 2010 Apr 1;120(5):1636–1644. doi: 10.1172/JCI38506

Figure 1. Induction of high titers of neutralizing Ab after vaccination correlates with large cutaneous lesion formation.

Figure 1

Neutralizing VV-specific antibody (NAb) titers (IU/ml) (A) and NT50 scores (B) in previously vaccinated volunteers at different time points after revaccination (kinetics from W0 to W8 were available for n = 36): W0, W4, W6, W8. The box-and-whisker plots show the median values and the 10th, 25th, 75th, and 90th percentiles. Statistical analyses were performed using the Wilcoxon matched pairs test; **P < 0.001, ***P < 0.0001. Dot plots of the size of skin lesions at day 8 (in mm) and the amplitude of NAb responses (IU/ml) in previously vaccinated individuals at W0 (n = 85) (C) and recently revaccinated individuals at W4 (n = 53) (D). (E) Dot plots of the size of skin lesions at day 8 (in mm) and the neutralizing titers of VV-specific Abs (NT50 scores) in previously vaccinated individuals at W0 (n = 55) (white circles) and recently revaccinated individuals at W4 (n = 53, black circles). Each circle represents data from 1 individual. All data are shown in the dot plot. Statistical analyses were performed using the Spearman test.