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. 2010 Apr 12;120(5):1627–1635. doi: 10.1172/JCI40145

Figure 4. Effects of HCTZ on urinary excretion of Na+ and Cl– in Ncc+/+ and Ncc–/– mice.

Figure 4

One single dose of HCTZ (50 mg/kg body weight) or vehicle was administered intraperitoneally to Ncc+/+ and Ncc–/– mice. Urine samples were collected from 0 to 6 and from 6 to 12 hours after injection to measure urinary Na+ (top panels) or Cl– (bottom panels) excretion. Results are expressed as the ratio to urinary creatinine. Statistical significance was assessed by 2-tailed Student’s unpaired t test. n = 5 in WT groups and n = 8 in KO groups; *P < 0.05, **P < 0.01 versus vehicle.