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. 2010 Apr 26;120(5):1617–1626. doi: 10.1172/JCI41678

Figure 4. Oxidized linoleic acid metabolites trigger acute pain and thermal hyperalgesia.

Figure 4

(A) Effects of an ipl hind paw injection in rats of 9-HODE or a mixture of 9-HODE, 13-HODE, 9-oxoODE, and 13-oxoODE (mix, 25 μg each) on spontaneous nocifensive behavior (duration of flinches; n = 4–6/group; *P < 0.05; **P = 0.003 vs. vehicle; ***P = 0.0001 vs. all other groups). Observers were blinded to treatment allocation. (B) Effects of an ipl injection of 9-HODE in WT or TRPV KO mice on paw withdrawal latency to a beam of radiant heat (n = 6 per group; P = 0.007 at 15 minutes).