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. 2010 Apr 19;120(5):1524–1534. doi: 10.1172/JCI40908

Figure 1. FAVL is a novel splice variant of FANCL to our knowledge and identical to human EST BQ574618.

Figure 1

(A) FAVL cDNA sequence. The cDNA sequence of FAVL is similar to the one of FANCL, with exons 10 and 11 of FANCL skipped. (B) Schematic protein structure comparison between FAVL and its cognate FANCL. FAVL has 272 aa, including 258 aa that are identical to FANCL and 14 unique aa that are translated from the junction region. (C) FAVL is identical to human EST BQ574816. Blast analysis of the fusion sequence, the end of exon 9 and the beginning of exon 12 of FANCL, shows that human EST BQ574618 matches the junction sequence (marked with red arrow), which is the unique part of FAVL (indicated with red arrow). Various colored boxes indicate exons.