Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model of the entry of SCH28080 into the luminal domain of the H,K ATPase on the top left, the path taken in the upper right image and the final binding site is show in the bottom image. In this model, valine 331 is substituted by phenylalanine to allow generation of sufficient space to allow inhibitor entry and exit via the water channel shown in Figure 21.
