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. Author manuscript; available in PMC: 2011 Apr 27.
Published in final edited form as: ACS Nano. 2010 Apr 27;4(4):2402–2410. doi: 10.1021/nn100190v

Figure 1.

Figure 1

PEG-mediated synthesis schematic of PEGylated iron oxide nanoparticles (ION). (A) Ferrous and ferric chloride dissolved in PEG (MW 600) with 2,2(ethylenedioxy)bis(ethylamine) (EDEA) under a N2 environment. (B) High temperature precipitation of ION at 120°C. (C) Solvent exchange to replace PEG with toluene. (D) Sequential surface modification of ION with (3-aminopropyl)trimethoxysilane (APS), PEG-diacid, and EDEA to form amine functionalized ION/PEG.