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. 2010 Apr 28;5(4):e10392. doi: 10.1371/journal.pone.0010392

Figure 1. Association between mr-gef and Dlx1 expression.

Figure 1

Regional expression of mr-gef, Lhx6 and Dlx1 in the E14.5 mouse ventral telencephalon (A–C). mr-gef and Lhx6 are expressed in the SVZ and mantle of the MGE (A,B respectively). mr-gef is expressed in regions adjacent to those in the VZ and SVZ expressing Dlx1 (A and C respectively) and in a band of cells reaching up into the Ctx (arrow A). A similar mr-gef expression pattern is observed in the ventral telencephalon in the Dlx1/2 heterozygote (+/−, D), with highest levels in the striatum (white arrow) and septum. Higher power magnification of striatum and cortex is shown in F and G respectively. In the Dlx1/2 double mutant telencephalon, mr-gef expression is greatly reduced, particularly in the striatum (black arrow, D'). Expression in the mutant striatum and cortex is shown at higher power in F' and G' respectively. For comparison, Lhx6 expression is shown in adjacent sections from the same heterozygote and mutant telencephalon (E and E' respectively), with a loss of Lhx6 expression in the cortex of the mutant (E'). Abbreviations: VZ, ventricular zone; SVZ, subventricular zone; MGE, medial ganglionic eminence; Str, striatum; Ctx, cortex; Sep, septum. Scale bars: 250 µm.