Table 1.
Physiological parameters at each experimental level
| BPsys (mmHg) | HR (min-1) | RPP (mmHg/min) | Flow (%) | SvO2 (%) | |
|---|---|---|---|---|---|
| BL1 | 95.9 ± 2.2 | 72.0 ± 3.9 | 6865 ± 276 | 100.0 ± 0 | 0 ± 0 |
| Ach1 | 95.6 ± 2.5 | 69.9 ± 3.2 | 6650 ± 258 | 127.7* ± 4.6 | 3.6 ± 2.3 |
| Ach2 | 98.3 ± 1.7 | 67.3 ± 3.9 | 6598 ± 263 | 186.2* ± 13.3 | 5.3 ± 2.1 |
| Ach3 | 99.1 ± 2.8 | 65.6 ± 3.5 | 6466 ± 282 | 309.7* ± 29.8 | 15. 7* ± 0.9 |
| BL2 | 98.5 ± 3.0 | 67.2 ± 3.5 | 6577 ± 232 | 107.5 ± 5.2 | 5.2 ± 2.0 |
| Ade1 | 97.7 ± 2.3 | 73.0 ± 3.2 | 7123 ± 304 | 817.9* ± 122.1 | 31.3* ± 2.6 |
| Ade2 | 95.6 ± 4.1 | 73.4 ± 2.7 | 7018 ± 410 | 410.4* ± 64.7 | 28.9* ± 1.2 |
| Ade3 | 99.0 ± 1.5 | 74.0 ± 8.7 | 7352 ± 981 | 532.2* ± 56.7 | 31.5* ± 0.6 |
| BL3 | 94.6 ± 2.2 | 71.6 ± 2.3 | 6769 ± 259 | 117.2 ± 6.4 | 4.4 ± 1.4 |
p < 0.05 compared to baseline
Mean values and SEM for systolic blood pressure (sysBP), heart rate (HR), rate-pressure product (RPP), flow in the left circumflex coronary artery (flow) relative to baseline 1 and change in coronary sinus oxygen saturation (SvO2) from baseline 1 at the different experimental levels (BL 1-3: baseline, ACh 1-3: intracoronary acetylcholine infusion/increasing doses, Ade 1-3: intracoronary adenosine infusion/increasing doses; detailed drug doses in the text). *: p < 0.05 vs. baseline (BL1).