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. 2010 Mar 31;10:121. doi: 10.1186/1471-2407-10-121

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Copyright ©2010 Sanders et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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SR/CR Nos2 Knockout Macrophages and Neutrophils Have No Detectable Nitric Oxide Production Following LPS and IFNγ Stimulation. Thioglycolate elicited macrophages and neutrophils were stimulated with LPS and IFNγ for 24 hours. Nitrite levels, an indirect measure of nitric oxide production, were assessed by the Griess Assay. Nitrite levels for WT (n = 5) and SR/CR (n = 5) Nos2^+/+macrophages were comparable, but significant levels of nitrites were not detected (n.d.) in SR/CR Nos2^-/-macrophages (n = 3). Nitrite levels for WT (n = 4) and SR/CR (n = 3) Nos2^+/+neutrophils were also comparable, but significant levels of nitrites were not detected in SR/CR Nos2^-/-neutrophils (n = 3).