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Despite decreased signal gain, the poly(A) loop construct exhibits better mismatch discrimination. The signal gain of the poly(A) sensor against a perfectly matched (PM) target is three times greater than that observed for a single mismatched target (1MM). In contrast, this ratio is only 1.6 for a poly(T) sensor, indicating a poorer level of discrimination. Neither structure responds significantly to a two or three mismatched target (2MM and 3MM respectively).
