Table 2.
Relative Concentrations of Three Cytokines Consistently Up-Regulated in Human AAAs Biopsies
| Experiment Cytokine | One
|
Two
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AAA | Atherothrombosis | Fold difference | P values* | FDR-adjusted P values | Body | Neck | Fold difference | P values† | FDR-adjusted P values | |
| CCL22 | 2.57 (2.01–3.03) | 1.40 (1.15–1.45) | 1.84 | 0.01 | 0.05 | 37.56 (36.08–39.59) | 17.24 (10.93–19.88) | 2.18 | 0.01 | 0.05 |
| IL1B | 1.93 (1.25–2.41) | 0.51 (0.05−0.92) | 3.78 | 0.01 | 0.05 | 49.80 (37.78–60.13) | 27.76 (21.09–33.39) | 1.79 | 0.01 | 0.05 |
| IL8 | 15.70 (13.53–17.79) | 7.68 (7.05–9.72) | 2.04 | 0.02 | 0.05 | 20.27 (17.79–24.90) | 9.76 (4.19–14.61) | 2.08 | 0.01 | 0.05 |
Shown are median and inter-quartile range of relative density units/ μg of protein. Only cytokines with relative concentrations consistently significantly different between AAA and atherothrombosis (study 1) and between body and neck of AAA biopsies (false discovery rate, FDR, adjusted P ≤ 0.05) are given. All other results are given in Supplementary Table S1 at http://ajp.amjpathol.org.
*
Statistical comparisons were made using Mann Whitney U * and Wilcoxon sign rank
†
tests. CCL22 = chemokine CC motif ligand 22; IL = interleukin.