Table 3.
Multivariate Analysis of the Relationship with HIF1A or EPAS1 (HIF-2a) in Colorectal Cancer
| Multivariate OR (95% CI) | P value | |
|---|---|---|
| Variables in the final model for HIF1A | ||
| PTGS2(COX-2) expression | 2.11 (1.28–3.43) | 0.0035 |
| CIMP-high (vs. CIMP-low/0) | 2.72 (1.24–6.00) | 0.013 |
| LINE-1 hypomethylation (for a 30% decrease) | 2.51 (1.18–5.35) | 0.017 |
| Female sex | 1.54 (0.95–2.49) | 0.083 |
| MSI-high (vs. MSI-low/MSS) | 0.50 (0.22–1.11) | 0.088 |
| Variables in the final model for EPAS1 | ||
| High tumor grade | 0.39 (0.22–0.70) | 0.0017 |
| Male sex | 1.48 (1.07–2.04) | 0.018 |
| BMI ≥ 30 kg/m2 (vs. <30 kg/m2) | 0.65 (0.43–0.98) | 0.039 |
| Mucinous component > 0% (vs. 0%) | 1.38 (0.99–1.91) | 0.057 |
Multivariate logistic regression analysis assessing the relationship with HIF1A or EPAS1 (as an outcome variable) initially included age, sex, body mass index, tumor location, stage, tumor grade, mucinous component, signet ring cell component, microsatellite instability, CpG island methylator phenotype, PTGS2, TP53, KRAS, PIK3CA, and BRAF. Backward stepwise elimination with threshold of P = 0.20 was used to select variables in the final model. A P value for significance was adjusted by Bonferroni correction to P = 0.0033.