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. 2010 May;176(5):2425–2434. doi: 10.2353/ajpath.2010.090932

Figure 3.

Figure 3

Percentage of regenerating fibers and functional properties of diaphragm muscle strips from young (16- to 17-day-old) C57BL/10 and mdx mice after five weeks treatment with either saline (Control) or myostatin inhibitory antibody (PF-354). Diaphragm strips from C57BL/10 mice did not exhibit any centrally nucleated fibers, and so the percentage of regenerating fibers is only shown for the mdx diaphragm (A). The specific force (sPo) was increased with PF-354 treatment in mdx mice (B). Progressive lengthening contractions (5%, 10%, 20%, 30%, and 40% stretches) leading to cumulative contraction-mediated damage in activated diaphragm muscle strips from C57BL/10 (C) and mdx mice (D). Data are means ± SEM, n = 6 to 8. *P < 0.001 versus Control.