Figure 5.

Histological and functional analyses of diaphragm muscle strips in adult (12-week-old) mdx mice after eight weeks treatment with either saline (Control) or myostatin inhibitory antibody (PF-354). Representative images of Van Gieson–stained tranverse sections (A) and the percentage infiltration of collagen (B). Specific force (sPo, C) and progressive lengthening contractions (2% to 50%) leading to cumulative contraction-mediated damage (D). Data are means ± SEM, n = 6 to 7. No significant differences were found between treatment.