Table 1.
Selected Morphometric Parameters of Young (16- to 17-Day-Old) C57BL/10 and mdx Mice after 5 Weeks Treatment with Either Saline (Control) or Myostatin Inhibitory Antibody (PF-354)
| Morphometric Parameter | C57BL/10
|
mdx | ||
|---|---|---|---|---|
| Control | PF-354 | Control | PF-354 | |
| Body mass, g | 23 ± 1 | 24 ± 1 | 23 ± 1 | 26 ± 1 |
| % increase body mass from initial | 208 ± 16 | 215 ± 1 | 197 ± 12 | 217 ± 9 |
| EDL/body mass, mg · g−1 | 0.23 ± 0.01 | 0.31 ± 0.01* | 0.31 ± 0.01 | 0.35 ± 0.01* |
| Soleus/body mass, mg · g−1 | 0.18 ± 0.02 | 0.24 ± 0.01* | 0.27 ± 0.01 | 0.30 ± 0.02 |
| Plantaris/body mass, mg · g−1 | 0.59 ± 0.03 | 0.68 ± 0.03 | 0.74 ± 0.03 | 0.78 ± 0.04 |
| TA/body mass, mg · g−1 | 1.63 ± 0.03 | 1.86 ± 0.05* | 2.27 ± 0.10 | 2.34 ± 0.09 |
| Gastrocnemius/body mass, mg · g−1 | 4.53 ± 0.10 | 4.89 ± 0.08 | 5.35 ± 0.12 | 5.92 ± 0.22* |
| Quadriceps/body mass, mg · g−1 | 6.89 ± 0.22 | 9.09 ± 0.34* | 8.87 ± 0.12 | 9.87 ± 0.29* |
| Heart mass, mg | 130.2 ± 3.7 | 126.1 ± 7.2 | 118.5 ± 6.3 | 125.4 ± 4.9 |
| Heart/body mass, mg · g−1 | 5.60 ± 0.15 | 5.38 ± 0.16 | 5.26 ± 0.23 | 4.84 ± 0.24 |
EDL indicates extensor digitorum longus; TA, tibialis anterior. Data are means ± SEM, n = 7 to 10.
*
P < 0.05 versus respective control strain.