Table 3.
Selected Morphometric Parameters of Adult (12-Week-Old) mdx Mice after 8 Weeks Treatment with Either Saline (Control) or Myostatin Inhibitory Antibody (PF-354)
| Morphometric Parameter | Control | PF-354 |
|---|---|---|
| Body mass, g | 37 ± 2 | 39 ± 1 |
| % increase body mass from initial | 17 ± 3 | 24 ± 3 |
| EDL/body mass, mg · g−1 | 0.40 ± 0.01 | 0.39 ± 0.04 |
| Soleus/body mass, mg · g−1 | 0.29 ± 0.01 | 0.27 ± 0.02 |
| Plantaris/body mass, mg · g−1 | 0.58 ± 0.03 | 0.66 ± 0.02* |
| TA/body mass, mg · g−1 | 2.41 ± 0.04 | 2.36 ± 0.07 |
| Gastrocnemius/body mass, mg · g−1 | 4.91 ± 0.19 | 5.08 ± 0.12 |
| Quadriceps/body mass, mg · g−1 | 9.42 ± 0.46 | 8.82 ± 0.57 |
| Heart mass, mg | 129.4 ± 3.7 | 131.6 ± 2.5 |
| Heart/body mass, mg · g−1 | 3.51 ± 0.05 | 3.42 ± 0.10 |
EDL indicates extensor digitorum longus; TA, tibialis anterior. Data are means ± SEM, n = 7.
*
P < 0.05 versus control.