Figure 4.

Impaired gland cell differentiation in human gastric Peutz-Jeghers polyps. A: Pepsinogen C or GS-lectin staining of sections from the base of an antral Peutz-Jeghers patient polyp or control gastric mucosa from a patient biopsy specimen (all micrographs at ×100 magnification; Scale bar = 200 μm). B: Staining for H⁺/K⁺-ATPase demonstrates deficiency in parietal cells in the polyp and staining for chromogranin A (CgA) shows presence of enteroendocrine cells in the base of a fundic Peutz-Jeghers patient polyp (at ×100 magnification; Scale bar = 200 μm). C: Comparison of gastrin positive cells in an antral and fundic polyp indicates presence according to the native site of occurrence (also at ×100 magnification; Scale bar = 200 μm).