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. 2010 May;176(5):2477–2489. doi: 10.2353/ajpath.2010.090049

Figure 2.

Figure 2

Patterns of LC3A expression in malignant breast tissues and the adjacent “normal” breast epithelium (magnification: large figures ×200, small figures ×1000). A: Diffuse cytoplasmic expression of LC3A in breast cancer cells (arrows). B: Juxta-nuclear pattern of LC3A expression in breast cancer cells (arrows). C: Stone-like structures within autophagic vacuoles (arrows) occupying almost the entire cytoplasm of breast cancer cells and pushing the nuclei toward the periphery. D: Nonmalignant “normal” breast glands in the proximity of the tumor with a mixed diffuse cytoplasmic and juxta-nuclear (arrows) LC3A expression.