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. 2010 May;176(5):2500–2508. doi: 10.2353/ajpath.2010.091041

Figure 1.

Figure 1

Reduction of IKKα expression promotes UVB skin carcinogenesis in mice. A: Skin tumor incidence in Ikkα+/+ (+/+) and Ikkα+/− (+/−) mice (P < 0.001, COX proportional hazards model). IKKα protein levels were detected by Western blotting. β-Actin, loading control. NS indicates nonspecific band. B: Tumor multiplicity in Ikkα+/+ and Ikkα+/− mice (P < 0.001, Poisson regression analysis). C: Tumor numbers in 33 Ikkα+/+ and 29 Ikkα+/− mice at week 28. D: Weight comparison of tumors found in 33 Ikkα+/+ and 29 Ikkα+/− mice (P < 0.05, t test). Lines indicate means; g, Gram (tumor weights).