Table 6. Summary of the genetic association of two coding variants in LOXL1 gene with XFS/XFG.
|
|
rs1048661
G allele |
|
rs3825942
G allele |
|
|
||
|---|---|---|---|---|---|---|---|
| Studied population | Case | Control | Significant association | Case | Control | Significant association | Reference |
| Icelandian |
0.781 |
0.651 |
Yes |
0.984 |
0.847 |
Yes |
[15] |
| Swedish |
0.834 |
0.682 |
Yes |
0.995 |
0.879 |
Yes |
[15] |
| American |
0.819 |
0.600 |
Yes |
0.986 |
0.880 |
Yes |
[16] |
| Australian |
0.78 |
0.660 |
Yes |
0.95 |
0.84 |
Yes |
[17] |
| American |
0.787 |
0.665 |
Yes |
0.939 |
0.844 |
Yes |
[18] |
| American |
NA |
NA |
NA |
1.000 |
0.856 |
Yes |
[19] |
| American |
0.843 |
0.703 |
Yes |
0.959 |
0.798 |
Yes |
[20] |
| Austrian |
0.841 |
0.671 |
Yes |
0.994 |
0.817 |
Yes |
[21] |
| Germany |
0.818 |
0.644 |
Yes |
0.951 |
0.857 |
Yes |
[22] |
| Italian |
0.825 |
0.693 |
Yes |
1.000 |
0.821 |
Yes |
[22] |
| Finnish |
0.825 |
0.683 |
Yes |
0.968 |
0.823 |
Yes |
[23] |
| Germany |
0.844 |
0.660 |
Yes |
0.992 |
0.856 |
Yes |
[24] |
| Chinese |
0.110 |
0.480 |
Yes |
1.000 |
0.900 |
Yes |
[25] |
| Japanese |
0.036 |
0.493 |
Yes |
1.000 |
0.877 |
Yes |
[26] |
| Japanese |
0.008 |
0.460 |
Yes |
1.000 |
0.857 |
Yes |
[27] |
| Japanese |
0.006 |
0.450 |
Yes |
0.994 |
0.853 |
Yes |
[28] |
| Japanese |
0.005 |
0.474 |
Yes |
0.995 |
0.850 |
Yes |
[29] |
| Japanese |
0.005 |
0.497 |
Yes |
0.986 |
0.863 |
Yes |
[30] |
| Japanese |
0.005 |
0.554 |
Yes |
0.993 |
0.806 |
Yes |
[31] |
| Indian |
0.721 |
0.634 |
No |
0.923 |
0.742 |
Yes |
[32] |
| Chinese |
0.542 |
0.444 |
No |
0.992 |
0.918 |
Yes |
[33] |
| American |
0.829 |
0.719 |
No |
0.988 |
0.795 |
Yes |
[34] |
| South African | 0.990 | 0.810 | Yes | 0.130 | 0.620 | Yes | This study |
In the table, NA indicates not available; LOXL1 indicates lysyl oxidase-like 1; XFS indicates exfoliation syndrome; and XFG indicates exfoliation glaucoma.