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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Hippocampus. 2010 May;20(5):596–607. doi: 10.1002/hipo.20665

Figure 3.

Figure 3

Binge alcohol administration reduces the number of BrdU+ cells, or cell proliferation, during alcohol intoxication in adolescent rats. A) To label cell proliferation, BrdU was injected 1 h after the last dose of alcohol or control diet and rats were sacrificed 2 h later. The number of BrdU+ cells is significantly decreased in binge alcohol exposed rats (EtOH, n=4) versus controls (n=5). Representative photomicrographs of BrdU+ clusters scattered along both blades of the dentate gyrus of the hippocampus are shown for control (B) and alcohol rats (D). Higher magnification images show representative BrdU+ cells from control (C) and alcohol-treated rats (E). GCL= Granule cell layer. Scale bars = 50 μm. *p< 0.05