Table 1. Intoxication parameters for the animal model.

The table above shows that all intoxication parameters are similar between the different time points. There were no significant differences between any of the four time points, thus differences in histological measures cannot be attributed to different intoxication levels between the groups.

	Intoxication Behavior (0–5 scale)	Dose (g/kg/day)	BEC (mg/dl)
4D (n= 6)	1.0 ± 0.1	12.5 ± 0.8	349.6 ± 18.3
4D + 2 (n= 8)	1.1 ± 0.2	11.8 ± 0.7	322.8 ± 18.7
4D + 7 (n= 8)	1.0 ± 0.1	13.2 ± 0.4	286.5 ± 18.8
4D + 28 (n=4)	1.0 ± 0.2	12.0 ± 0.5	231.9 ± 17.5