Figure 5.

Stimulus-evoked activity simulated using the model. a, Evoked responses were simulated by driving the models of Figure 4 with an α-function kick driving force ε(t) starting from different activity states at time t = 0 (colored dots). b, Time-domain representation. Simulated responses in the synchronized state are highly sensitive to activity state at the time of the stimulus and exhibit stimulus-evoked flips: up–down and down–up transitions. In the desynchronized state, simulated responses are more stereotyped and less dependent on initial conditions. c, Same as in b, but each response is generated from a noisy driving force ε(t) (bottom black trace), obtained by adding noise as in Figure 4 to the kick in (a, b). synch, Synchronized; desynch, desynchronized.