(A) A skin biopsy specimen obtained from the lower lip showed a well-defined mucous retention cyst with complete definitive epithelial lining in the lamina propria. (B) A skin biopsy specimen from the lower lip showed intermixing of mucus and granulation tissue in the submucosa. (C) Inside a well-defined cavity, faintly eosinophilic amorphous material, vacuolated macrophages, lymphocytes, and a few eosinophils were observed (A, B: H&E stain, ×40, C: H&E stain, ×400).